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KMID : 0654219920010000157
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Journal of Asan Welfare Foundation Haesung General Hospital
1992 Volume.1 No. 0 p.157 ~ p.163
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Pathological Studies on the Effects of Phenobarbital upon Chronic Hepatic Lesions induced by Dimethylnitrosamine
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Abstract
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In an attempt to elucidate the pathological effects of phenobarbital on dimethylnitrosamine . (DMN) induced chronic hepatic lesions, the present studies in the male Sprague-Dawley rats was undertaken to evaluate the number of dysplastic cells and the average nuclear size of 15, 45, 75 and 105 days after DMN injections.
The results were as follows
1. The liver dysplastic cells were present in the DMN treated group, while they were absent in the control.
2. The liver dysplastic cells in the DMN+phenobarbital treated group were more prominent than those of the DMN treated group.
3. The average nuclear size(0.59 to 0.71cm) of dysplastic cells in the DMN treated group was much larger(1.3 to 1.6 times) than that of the control (0.45 to 0.48cm).
4. The average nuclear size(0.63 to 0.71cm) of dysplastic cells in the DMN+phenobarbital treated group was much larger than that of the DMN treated group (0.59 to 0.68cm).
In summary, the result obtained by the present study indicates dimethylnitrosamine induces liver cell dysplasia.
The observation also suggests phenobarbital ptomoted DMN induced liver cell dysplasia.
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